For laboratory research use only. Not for human consumption.
Talk to our research support team: 512-998-2437
For laboratory research use only. Not for human consumption.
Talk to our research support team: 512-998-2437
Price range: $25.00 through $450.00
These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.
Research Use Only
All research peptides supplied by OPTMZ Peptides are intended strictly for laboratory research applications and are not designed for medical use. These materials are not approved by the U.S. Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer confirms use strictly for scientific research purposes and not for human or animal consumption.
Product Overview
GHK-Cu is a copper-binding tripeptide complex consisting of the naturally occurring peptide glycyl-L-histidyl-L-lysine (GHK) coordinated with copper.
GHK-Cu is investigated in controlled laboratory environments for its role in copper coordination, extracellular-matrix biology, fibroblast signaling, collagen-associated pathways, tissue-remodeling models, oxidative-stress responses, and cellular gene-expression research.
The histidine residue within GHK contributes importantly to copper coordination, giving the complex biochemical properties distinct from the uncomplexed GHK tripeptide.
The lot-specific purity, measured content, identity, and CAS number come directly from the Krause Analytical COA.
Each tested batch of GHK-Cu undergoes analytical evaluation to verify chromatographic purity, identity, compound content, and analytical consistency.
For the submitted OPTMZ Peptides sample, Krause Analytical reported:
The laboratory states that the analyzed sample met its internal quality-assurance criteria unless otherwise flagged.
The chromatogram on page 2 shows a dominant chromatographic peak at approximately 0.57 minutes, while the mass-spectrum/reference-spectrum comparison shows closely corresponding major signals for sample 200515 and the GHK-Cu reference, including prominent signals around m/z 342 and 403.
Endotoxin Status: Not reported on this COA.
This batch should therefore not be described as endotoxin-tested, endotoxin-free, or as having passed endotoxin testing based on this certificate.
GHK-Cu should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve peptide integrity and copper-peptide complex stability.
Avoid unnecessary exposure to heat, moisture, light, and repeated temperature fluctuations. Experimental preparation, storage, and handling should follow validated laboratory procedures appropriate to the intended research application.
GHK-Cu is investigated extensively in peptide biology, extracellular-matrix research, fibroblast biology, copper homeostasis, and cellular remodeling models.
Research areas include:
GHK was originally identified as a naturally occurring copper-binding peptide in human plasma. Research subsequently examined GHK-Cu across multiple experimental systems involving extracellular-matrix remodeling, cellular signaling, and gene expression.
These observations describe experimental research contexts and should not be interpreted as established therapeutic or cosmetic effects of the OPTMZ research product.
GHK-Cu is relevant to controlled experimental investigations involving copper-dependent peptide biology, extracellular-matrix regulation, fibroblast behavior, collagen-associated signaling, matrix remodeling, oxidative-stress pathways, and cellular gene-expression responses.
The molecule is particularly useful in research examining how a small endogenous peptide can coordinate a transition metal and influence biochemical and cellular processes differently from the corresponding unbound peptide.
For laboratory research use only. Intended strictly for in vitro and controlled experimental research applications.
All products currently listed on this site are for research purposes ONLY.
The lot-specific purity, measured content, identity, and CAS number come directly from the Krause Analytical COA.
Each tested batch of GHK-Cu undergoes analytical evaluation to verify chromatographic purity, identity, compound content, and analytical consistency.
For the submitted OPTMZ Peptides sample, Krause Analytical reported:
The laboratory states that the analyzed sample met its internal quality-assurance criteria unless otherwise flagged.
The chromatogram on page 2 shows a dominant chromatographic peak at approximately 0.57 minutes, while the mass-spectrum/reference-spectrum comparison shows closely corresponding major signals for sample 200515 and the GHK-Cu reference, including prominent signals around m/z 342 and 403.
Endotoxin Status: Not reported on this COA.
This batch should therefore not be described as endotoxin-tested, endotoxin-free, or as having passed endotoxin testing based on this certificate.
GHK-Cu should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve peptide integrity and copper-peptide complex stability.
Avoid unnecessary exposure to heat, moisture, light, and repeated temperature fluctuations. Experimental preparation, storage, and handling should follow validated laboratory procedures appropriate to the intended research application.
GHK-Cu is investigated extensively in peptide biology, extracellular-matrix research, fibroblast biology, copper homeostasis, and cellular remodeling models.
Research areas include:
GHK was originally identified as a naturally occurring copper-binding peptide in human plasma. Research subsequently examined GHK-Cu across multiple experimental systems involving extracellular-matrix remodeling, cellular signaling, and gene expression.
These observations describe experimental research contexts and should not be interpreted as established therapeutic or cosmetic effects of the OPTMZ research product.
GHK-Cu is relevant to controlled experimental investigations involving copper-dependent peptide biology, extracellular-matrix regulation, fibroblast behavior, collagen-associated signaling, matrix remodeling, oxidative-stress pathways, and cellular gene-expression responses.
The molecule is particularly useful in research examining how a small endogenous peptide can coordinate a transition metal and influence biochemical and cellular processes differently from the corresponding unbound peptide.
For laboratory research use only. Intended strictly for in vitro and controlled experimental research applications.
All products currently listed on this site are for research purposes ONLY.
| Pcs | Single Vial, Pack of 10 |
|---|---|
| Strength | 50mg, 100mg |
Copper-Binding Tripeptide / Copper-Peptide Coordination Complex
Peptide Biology; Metallobiochemistry; Extracellular-Matrix Biology; Cell Biology; Connective-Tissue Research; Molecular Biology
No single validated receptor target established A more scientifically accurate description is: Copper coordination / extracellular-matrix and gene-regulatory signaling networks GHK-Cu is not best characterized as a conventional single-receptor agonist. Research instead involves multiple cellular and biochemical pathways associated with copper transport, extracellular-matrix regulation, fibroblast signaling, oxidative stress, and gene expression.
Preclinical / Experimental Research GHK-Cu has a substantial biochemical, cellular, tissue, and preclinical research literature. Some human/cosmetic research involving copper peptides also exists, but claims made for the OPTMZ research material should remain limited to laboratory research rather than implying established clinical efficacy.
GHK-Cu is a copper-peptide coordination complex formed from the tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys; GHK) and a copper ion. The peptide contains glycine, histidine, and lysine residues, with the histidine imidazole group and peptide-associated donor atoms participating in copper coordination. This metal-binding architecture distinguishes GHK-Cu from uncomplexed GHK and is central to research involving its biochemical properties.
7. Amino Acid Sequence amino_acid_sequence Gly-His-Lys One-letter sequence: GHK Peptide component: Glycyl-L-histidyl-L-lysine Metal complex: GHK + Cu²⁺ → GHK-Cu
Copper-peptide coordination studies
Fibroblast biology
Collagen-associated pathway research
Extracellular-matrix studies
Matrix-remodeling research
Cellular migration assays
Gene-expression studies
Oxidative-stress research
Antioxidant pathway analysis
Matrix metalloproteinase research
Angiogenesis-associated models
Connective-tissue biology
Hair-follicle experimental models
Peptide-metal structure-function studies
Relevant experimental systems include:
Human dermal fibroblast cultures
Keratinocyte systems
Extracellular-matrix models
Collagen-production models
Cellular migration systems
Oxidative-stress cell models
Gene-expression profiling systems
Connective-tissue models
Hair-follicle cell systems
Angiogenesis-associated cell models
Peptide-metal binding systems
Tissue-remodeling experimental models
HPLC-UV chromatographic purity analysis
LC-MS identity confirmation
Mass-spectral analysis
Copper-binding assays
Collagen synthesis assays
Fibroblast proliferation assays
Cellular migration assays
Gene-expression profiling
qPCR
Matrix metalloproteinase assays
Oxidative-stress assays
Reactive oxygen species assays
Antioxidant enzyme assays
Extracellular-matrix analysis
Angiogenesis-associated assays
For the actual OPTMZ lot, Krause Analytical specifically documented HPLC-UV-MS analysis.
Chromatographic purity
GHK-Cu identity
GHK-Cu content
Copper-binding behavior
Collagen-associated expression
Extracellular-matrix production
Fibroblast activity
Cellular migration
Matrix metalloproteinase activity
Gene-expression changes
Oxidative-stress markers
Reactive oxygen species
Antioxidant enzyme activity
Angiogenesis-associated responses
For the actual OPTMZ sample, the directly measured analytical endpoints were chromatographic purity, GHK-Cu identity, and GHK-Cu content.
Independent analytical testing of OPTMZ Peptides GHK-Cu 50 mg, lab sample 200515, by Krause Analytical reported:
Chromatographic Purity: >99.9%
GHK-Cu Content: 43.4 mg
Label Claim: 50 mg
Percent of Label: 86.7%
Identity: GHK-Cu confirmed
CAS Number: 49557-75-7
Analysis Method: HPLC-UV-MS
Lab Number: 200515
Project: 145030
Date Received: January 29, 2026
Report Issued: February 9, 2026
Endotoxin Testing: Not reported on current COA
The COA states that the data are from the analyzed sample and meet Krause Analytical's internal quality-assurance criteria unless otherwise flagged.
Page 2 additionally provides the chromatogram and the sample-versus-reference mass spectra supporting the analytical characterization.
Restricted Access · Research Use Only
Independently lab tested, every batch
COAs published and searchable by batch number
Policy version 2026-05-14-ruo-v1.0
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