For laboratory research use only. Not for human consumption.
Talk to our research support team: 512-998-2437
For laboratory research use only. Not for human consumption.
Talk to our research support team: 512-998-2437
Price range: $35.00 through $330.00
These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.
Research Use Only
All research peptides supplied by OPTMZ Peptides are intended strictly for laboratory research applications and are not designed for medical use. These materials are not approved by the U.S. Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer confirms use strictly for scientific research purposes and not for human or animal consumption.
Product Overview
Gonadorelin is the synthetic form of naturally occurring gonadotropin-releasing hormone (GnRH), also historically known as luteinizing hormone-releasing hormone (LHRH). It is a decapeptide investigated in endocrine research involving GnRH receptor signaling, pituitary gonadotroph biology, and the hypothalamic-pituitary-gonadal (HPG) axis.
Gonadorelin interacts with the gonadotropin-releasing hormone receptor (GnRHR), a G-protein-coupled receptor expressed prominently on anterior pituitary gonadotroph cells. GnRH receptor activation is associated with signaling pathways regulating the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). USP identifies gonadorelin acetate as a synthetic peptide hormone with gonadotropin-releasing activity.
The lot-specific identity, purity, net content, appearance, and endotoxin results come directly from the Freedom Diagnostics COA.
The FDA’s substance database identifies gonadorelin as CAS 33515-09-2 and PubChem CID 638793.
Important acetate distinction: The COA product is labeled Gonadorelin Acetate, but its analytical identity result is simply Gonadorelin and the COA does not specify acetate stoichiometry. USP describes gonadorelin acetate as C₅₅H₇₅N₁₇O₁₃·xC₂H₄O₂·yH₂O, meaning acetate and hydration can vary. For that reason, I would use the well-defined gonadorelin base formula and molecular weight in the structural fields and identify the marketed material separately as Gonadorelin Acetate rather than assigning an unsupported fixed acetate stoichiometry.
Each tested batch of Gonadorelin Acetate undergoes analytical evaluation to verify peptide identity, chromatographic purity, content, and analytical consistency.
For the submitted OPTMZ Peptides sample, Freedom Diagnostics reported:
The laboratory states that endotoxin testing was performed using the Limulus Amebocyte Lysate assay in accordance with USP <85>, while peptide characterization used HPLC with UV detection coupled with mass spectrometry.
The single-page COA also displays the chromatogram and mass-confirmation spectrum beneath the analytical-results table.
Gonadorelin Acetate should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve peptide stability and structural integrity.
Avoid unnecessary exposure to heat, moisture, light, and repeated temperature fluctuations. Experimental preparation, storage, and handling should follow validated laboratory procedures appropriate to the intended research application.
Gonadorelin is investigated primarily in endocrine and reproductive-biology research involving the hypothalamic-pituitary-gonadal axis.
Research areas include:
The peptide’s sequence is equivalent to endogenous mammalian GnRH, making it particularly useful for studying physiological GnRH-receptor signaling rather than the modified pharmacology of longer-acting GnRH analogs. FDA material describes gonadorelin as the generic name for naturally occurring and synthetic GnRH and identifies it as a decapeptide whose sequence is identical to the natural hormone.
GnRH receptor research has included receptor-binding assays and studies examining how peptide modifications alter receptor affinity and biological activity.
Gonadorelin is relevant to controlled experimental investigations involving GnRH receptor activation, gonadotropin release, pituitary signaling, reproductive endocrinology, receptor-binding kinetics, and hypothalamic-pituitary communication.
Its status as a synthetic version of native GnRH also makes it useful as a reference ligand in comparative studies involving modified GnRH agonists and antagonists.
For laboratory research use only. Intended strictly for in vitro and controlled experimental research applications.
All products currently listed on this site are for research purposes ONLY.
The lot-specific identity, purity, net content, appearance, and endotoxin results come directly from the Freedom Diagnostics COA.
The FDA’s substance database identifies gonadorelin as CAS 33515-09-2 and PubChem CID 638793.
Important acetate distinction: The COA product is labeled Gonadorelin Acetate, but its analytical identity result is simply Gonadorelin and the COA does not specify acetate stoichiometry. USP describes gonadorelin acetate as C₅₅H₇₅N₁₇O₁₃·xC₂H₄O₂·yH₂O, meaning acetate and hydration can vary. For that reason, I would use the well-defined gonadorelin base formula and molecular weight in the structural fields and identify the marketed material separately as Gonadorelin Acetate rather than assigning an unsupported fixed acetate stoichiometry.
Each tested batch of Gonadorelin Acetate undergoes analytical evaluation to verify peptide identity, chromatographic purity, content, and analytical consistency.
For the submitted OPTMZ Peptides sample, Freedom Diagnostics reported:
The laboratory states that endotoxin testing was performed using the Limulus Amebocyte Lysate assay in accordance with USP <85>, while peptide characterization used HPLC with UV detection coupled with mass spectrometry.
The single-page COA also displays the chromatogram and mass-confirmation spectrum beneath the analytical-results table.
Gonadorelin Acetate should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve peptide stability and structural integrity.
Avoid unnecessary exposure to heat, moisture, light, and repeated temperature fluctuations. Experimental preparation, storage, and handling should follow validated laboratory procedures appropriate to the intended research application.
Gonadorelin is investigated primarily in endocrine and reproductive-biology research involving the hypothalamic-pituitary-gonadal axis.
Research areas include:
The peptide’s sequence is equivalent to endogenous mammalian GnRH, making it particularly useful for studying physiological GnRH-receptor signaling rather than the modified pharmacology of longer-acting GnRH analogs. FDA material describes gonadorelin as the generic name for naturally occurring and synthetic GnRH and identifies it as a decapeptide whose sequence is identical to the natural hormone.
GnRH receptor research has included receptor-binding assays and studies examining how peptide modifications alter receptor affinity and biological activity.
Gonadorelin is relevant to controlled experimental investigations involving GnRH receptor activation, gonadotropin release, pituitary signaling, reproductive endocrinology, receptor-binding kinetics, and hypothalamic-pituitary communication.
Its status as a synthetic version of native GnRH also makes it useful as a reference ligand in comparative studies involving modified GnRH agonists and antagonists.
For laboratory research use only. Intended strictly for in vitro and controlled experimental research applications.
All products currently listed on this site are for research purposes ONLY.
| Pcs | Single Vial, Pack of 10 |
|---|---|
| Strength | 5mg |
Gonadotropin-Releasing Hormone / GnRH Receptor Agonist
Reproductive Endocrinology; Peptide Biology; Pituitary Biology; GnRH Receptor Research; Neuroendocrinology; Reproductive Biology
Gonadotropin-Releasing Hormone Receptor (GnRHR / GnRH1R) GnRHR is the principal receptor through which GnRH regulates anterior pituitary gonadotroph signaling and gonadotropin secretion.
Established Clinical Research Gonadorelin has extensive experimental and human clinical research history, and the molecule has also been used in regulated pharmaceutical products. This classification describes the evidence base surrounding the molecule and does not mean the OPTMZ research product is FDA-approved or intended for clinical use.
Gonadorelin is a synthetic decapeptide structurally identical to endogenous gonadotropin-releasing hormone (GnRH). It consists of ten amino-acid residues with an N-terminal pyroglutamyl residue and an amidated C-terminus. This compact peptide structure functions as the endogenous ligand framework for the GnRH receptor and serves as a reference molecule for studying GnRH receptor signaling and modified GnRH analogs.
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ One-letter-style representation: pE-H-W-S-Y-G-L-R-P-G-NH₂ This is the native mammalian GnRH decapeptide sequence; FDA documentation notes that gonadorelin has the same amino-acid sequence as the natural hormone.
GnRH receptor signaling studies
GnRH receptor-binding research
Pituitary gonadotroph studies
LH secretion research
FSH secretion research
Hypothalamic-pituitary-gonadal axis research
Pulsatile GnRH signaling models
GnRH receptor desensitization studies
GnRH agonist/antagonist comparison
Reproductive endocrine signaling
Peptide structure-function analysis
Relevant published experimental systems include:
GnRH receptor-expressing cell systems
Isolated pituitary-cell models
Anterior pituitary gonadotroph models
Receptor-transfected cell systems
GnRH receptor-binding models
Gonadotropin secretion systems
Reproductive endocrine models
Human ovarian tissue research systems
Comparative GnRH agonist/antagonist models
GnRH receptor-binding studies have been performed in isolated pituitary cells and receptor-expression systems.
HPLC-UV purity analysis
LC-MS identity confirmation
Mass-confirmation analysis
LAL endotoxin assay
GnRH receptor-binding assays
Competitive ligand-binding assays
LH secretion assays
FSH secretion assays
Gonadotroph response assays
Receptor activation assays
Intracellular signaling assays
Receptor desensitization/internalization studies
For the actual OPTMZ lot, Freedom Diagnostics specifically documents HPLC-UV, LC-MS, and USP LAL endotoxin testing.
Chromatographic purity
Peptide identity
Net peptide content
Endotoxin assay result
GnRH receptor binding
LH release
FSH release
Gonadotroph signaling
Receptor activation
Ligand-binding affinity
Receptor desensitization
Intracellular signaling responses
For the actual OPTMZ sample, the directly measured analytical endpoints were identity, purity, net content, appearance, and endotoxin assay performance.
Independent analytical testing of OPTMZ Peptides Gonadorelin Acetate 5 mg, lot GND5, by Freedom Diagnostics reported:
Purity (HPLC-UV): 99.94%
Identity (LC-MS): Gonadorelin confirmed
Measured Net Content: 5.84 mg
Label Claim: 5 mg
Appearance: White lyophilized powder
Endotoxin Replicate 1: PASS
Endotoxin Replicate 2: PASS
Assay Sensitivity: ≤0.05 EU/mL
Endotoxin Method: Limulus Amebocyte Lysate assay in accordance with USP
Analytical Method: HPLC with UV detection coupled with LC-MS
Lot: GND5
Accession #: 2606080472
Received: June 8, 2026
Reported: June 9, 2026
These values come directly from the Freedom Diagnostics Certificate of Analysis for the submitted sample.
Restricted Access · Research Use Only
Independently lab tested, every batch
COAs published and searchable by batch number
Policy version 2026-05-14-ruo-v1.0
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