For laboratory research use only. Not for human consumption.
Talk to our research support team: 512-998-2437
For laboratory research use only. Not for human consumption.
Talk to our research support team: 512-998-2437
Price range: $60.00 through $550.00
These products are for laboratory research only and not intended for medical use. They are not FDA-approved to diagnose, treat, cure, or prevent any disease. By purchasing, you certify they will be used solely for research and not for human or animal consumption.
Research Use Only
All research peptides supplied by OPTMZ Peptides are intended strictly for laboratory research applications and are not designed for medical use. These materials are not approved by the U.S. Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer confirms use strictly for scientific research purposes and not for human or animal consumption.
Product Overview
KPV is a synthetic tripeptide composed of the amino acids lysine, proline, and valine. It corresponds to the C-terminal amino-acid sequence 11–13 of alpha-melanocyte-stimulating hormone (α-MSH) and is investigated in controlled laboratory environments for its interactions with inflammatory signaling, intestinal epithelial biology, immune-cell pathways, and peptide transport mechanisms.
Experimental research has examined KPV in cellular and animal models involving NF-κB and MAP kinase signaling, pro-inflammatory cytokine expression, intestinal epithelial cells, immune cells, and peptide transporter 1 (PepT1)-mediated cellular uptake.
The CAS number, chromatographic purity, measured content, identity confirmation, and endotoxin result above come directly from the Krause Analytical COA for the tested OPTMZ sample.
Each tested batch of KPV undergoes analytical evaluation to verify chromatographic purity, identity, peptide content, and analytical consistency. A corresponding Certificate of Analysis is maintained for the tested lot.
For the submitted OPTMZ Peptides sample, independent testing by Krause Analytical reported:
The laboratory specifies that all values are reported on a per-vial basis unless otherwise noted.
The accompanying COA also includes the underlying chromatogram on page 2, which shows a dominant principal peak, and the mass-spectral report on page 3 supporting the identity analysis.
KPV should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve peptide stability and structural integrity.
Avoid unnecessary exposure to heat, moisture, and repeated temperature fluctuations. Experimental preparation, storage, and handling should follow validated laboratory procedures appropriate to the intended research application.
KPV has been investigated in experimental systems involving inflammatory signaling, intestinal epithelial biology, immune-cell signaling, and melanocortin-derived peptide biology.
Research areas include:
A published study using human intestinal epithelial cells and Jurkat T cells found KPV uptake was associated with PepT1 and examined NF-κB, MAP kinase pathways, and pro-inflammatory cytokine secretion. The same study also evaluated KPV in DSS- and TNBS-induced mouse colitis models.
Other experimental research has examined KPV in DSS and CD45RB-high transfer models of intestinal inflammation and reported that some observed activity persisted in mice with nonfunctional MC1R, suggesting that KPV’s experimental signaling cannot simply be attributed to conventional MC1R activation.
These findings describe preclinical experimental research and do not establish therapeutic efficacy or safety in humans.
KPV continues to be evaluated as an experimental research peptide for investigating inflammatory signaling, intestinal peptide transport, epithelial-cell responses, immune-cell biology, and molecular pathways associated with α-MSH-derived peptides.
Its three-amino-acid Lys-Pro-Val structure represents the C-terminal tripeptide of α-MSH. Despite lacking much of the parent peptide’s structure, KPV has retained biological activity in multiple experimental inflammatory models, making it useful for investigating structure-function relationships among melanocortin-derived peptides.
For laboratory research use only. Intended strictly for in vitro and controlled experimental research applications.
All products currently listed on this site are for research purposes ONLY.
The CAS number, chromatographic purity, measured content, identity confirmation, and endotoxin result above come directly from the Krause Analytical COA for the tested OPTMZ sample.
Each tested batch of KPV undergoes analytical evaluation to verify chromatographic purity, identity, peptide content, and analytical consistency. A corresponding Certificate of Analysis is maintained for the tested lot.
For the submitted OPTMZ Peptides sample, independent testing by Krause Analytical reported:
The laboratory specifies that all values are reported on a per-vial basis unless otherwise noted.
The accompanying COA also includes the underlying chromatogram on page 2, which shows a dominant principal peak, and the mass-spectral report on page 3 supporting the identity analysis.
KPV should be handled by qualified professionals in controlled laboratory environments. Appropriate storage conditions should be maintained to preserve peptide stability and structural integrity.
Avoid unnecessary exposure to heat, moisture, and repeated temperature fluctuations. Experimental preparation, storage, and handling should follow validated laboratory procedures appropriate to the intended research application.
KPV has been investigated in experimental systems involving inflammatory signaling, intestinal epithelial biology, immune-cell signaling, and melanocortin-derived peptide biology.
Research areas include:
A published study using human intestinal epithelial cells and Jurkat T cells found KPV uptake was associated with PepT1 and examined NF-κB, MAP kinase pathways, and pro-inflammatory cytokine secretion. The same study also evaluated KPV in DSS- and TNBS-induced mouse colitis models.
Other experimental research has examined KPV in DSS and CD45RB-high transfer models of intestinal inflammation and reported that some observed activity persisted in mice with nonfunctional MC1R, suggesting that KPV’s experimental signaling cannot simply be attributed to conventional MC1R activation.
These findings describe preclinical experimental research and do not establish therapeutic efficacy or safety in humans.
KPV continues to be evaluated as an experimental research peptide for investigating inflammatory signaling, intestinal peptide transport, epithelial-cell responses, immune-cell biology, and molecular pathways associated with α-MSH-derived peptides.
Its three-amino-acid Lys-Pro-Val structure represents the C-terminal tripeptide of α-MSH. Despite lacking much of the parent peptide’s structure, KPV has retained biological activity in multiple experimental inflammatory models, making it useful for investigating structure-function relationships among melanocortin-derived peptides.
For laboratory research use only. Intended strictly for in vitro and controlled experimental research applications.
All products currently listed on this site are for research purposes ONLY.
| Pcs | Single Vial, Pack of 10 |
|---|---|
| Strength | 10mg |
Anti-Inflammatory Research Peptide / Melanocortin-Derived Tripeptide
Immunology; Cell Biology; Gastrointestinal Biology; Molecular Signaling; Peptide Biology
Peptide Transporter 1 (PepT1/SLC15A1); NF-κB and MAPK-associated inflammatory signaling pathways KPV has been experimentally demonstrated to undergo PepT1-mediated uptake in intestinal epithelial and immune-cell systems. Its downstream experimental effects include modulation of NF-κB and MAP kinase signaling.
The research supporting these applications consists predominantly of cellular, biochemical, and animal-model studies rather than established human clinical evidence.
KPV is a linear tripeptide composed of lysine, proline, and valine (Lys-Pro-Val). It corresponds to the C-terminal three-amino-acid sequence of α-melanocyte-stimulating hormone (α-MSH 11–13). Its compact structure has made KPV useful in experimental investigations of melanocortin-derived peptide signaling and peptide structure-function relationships.
Lys-Pro-Val
Inflammatory signaling research
NF-κB pathway studies
MAP kinase pathway studies
Cytokine-expression research
PepT1 peptide-transport studies
Intestinal epithelial-cell research
Immune-cell signaling
Melanocortin-derived peptide research
Peptide uptake studies
Gastrointestinal experimental models
Peptide structure-function analysis
Published experimental systems involving KPV include:
Caco2-BBE human intestinal epithelial cells
HT29-Cl.19A intestinal epithelial cells
Jurkat human T cells
Human keratinocyte models
PepT1 transport systems
DSS-induced mouse colitis models
TNBS-induced mouse colitis models
CD45RB-high transfer colitis models
MC1R-deficient experimental models
These are published research systems and do not represent approved clinical applications
NF-κB luciferase reporter assays
Western blot analysis
Real-time RT-PCR
ELISA
PepT1 uptake/competition assays
Radiolabeled KPV uptake assays
MAP kinase phosphorylation analysis
Cytokine-expression assays
Histological analysis
Myeloperoxidase (MPO) activity assays
HPLC-UV purity analysis
Mass-spectral identity analysis
USP endotoxin testing
The cellular research literature specifically reports NF-κB luciferase, Western blot, RT-PCR, ELISA, and peptide-uptake experiments.
NF-κB activation
IκB-α degradation and phosphorylation
ERK1/2 phosphorylation
JNK phosphorylation
p38 MAPK phosphorylation
Pro-inflammatory cytokine expression
Cytokine secretion
PepT1-mediated peptide uptake
Histological inflammatory changes
MPO activity
Cellular inflammatory responses
For the OPTMZ product itself, analytical endpoints include chromatographic purity, identity, KPV content, and endotoxin concentration.
Independent analytical testing of OPTMZ Peptides KPV 10 mg, batch/lot 2026/02, by Krause Analytical reported:
Chromatographic Purity: 99.6%
KPV Content: 8.86 mg
Label Claim: 10 mg
Percent of Label: 88.6%
Identity: Mass spectral match confirmed
CAS Number: 112965-21-6
Analysis Method: HPLC-UV-MS
Endotoxins: <0.5 EU/mL
Endotoxin Method: USP
Lab Number: 205091
Project: 145211
The COA states that values are reported per vial unless otherwise noted.
Restricted Access · Research Use Only
Independently lab tested, every batch
COAs published and searchable by batch number
Policy version 2026-05-14-ruo-v1.0
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